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. 2019 Feb 27;9:2950. doi: 10.1038/s41598-019-39588-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The I65M NEMO mutant mimics the open bun conformation. NEMO-EEAA (blue), NEMO-I65M (orange) and NEMO in the IKKβ complex (PDB: 3BRV, grey). (a) Proteins displayed as transparent ribbons encompassing residues 55–81 are superimposed on chain A. The angle between the helix axis for NEMO-EEAA and NEMO-I65M is shown by the arrows in the region 57–77: 5.66 degrees. (b) Effect of the Met/Ile mutation (shown as sticks).