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. 2019 Feb 27;9:2895. doi: 10.1038/s41598-019-39681-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of deSUMOylation inhibits insulin secretion. (A) Western blot showing whole cell SUMOylation (above) and alpha-tubulin (below) levels in cells infected with control virus (1), SUMO-1GG virus (2), SUMO-1dGG virus (3) and SUMO-1QP virus (4). The image shows lanes cropped from a single Western blot, to exclude an irrelevant lane that was run as part of the same experiment. For the full blot, please see Supplementary Information. (B) GSIS in INS-1E cells infected with control or SUMO-1GG overexpressing virus, expressed as fold increase in insulin secretion. No significant differences were noted (n = 6). (C) GSIS in INS-1E cells infected with control or SUMO-1QP overexpressing virus, expressed as fold increase in insulin secretion. *p < 0.05, Student’s t-test (n = 6). Full, uncropped blots are shown in Supplementary Data. Data are presented +/− SEM.