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. 2019 Feb 27;5:4. doi: 10.1038/s41537-019-0072-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Epigenetic age acceleration analysis of the first cohort. a Scatter-plot of DNA methylation age vs. chronological age. Spearman’s correlation analysis indicates a significant positive correlation or trend toward positive correlation between chronological age and DNA methylation age in SCZ and control groups. b, c, d Violin-plots of measures of epigenetic age acceleration. Mann–Whitney U-test was performed for comparisons between SCZ and control groups. CTL, control; SCZ, schizophrenia; AgeAccel, universal epigenetic age acceleration; IEAA, intrinsic epigenetic age acceleration; EEAA, extrinsic epigenetic age acceleration