Table 2.
GCN Edge-RCC mutation Association.
| Mutation | Gene Description | RCC-GCN | Tumor-GCN | Normal-GCN |
|---|---|---|---|---|
| VHL | von Hippel-Lindau tumor suppressor | 5282 | 1755 | 2330 |
| PBRM1 | polybromo 1 | 4254 | 1362 | 2274 |
| SETD2 | SET domain containing 2 | 265 | 67 | 170 |
| KDM5C | lysine demethylase 5C | 41 | 33 | 1 |
| BAP1 | BRCA1 associated protein 1 | 41 | 29 | 0 |
| PTEN | phosphatase and tensin homolog | 1 | 0 | 0 |
| MTOR | mechanistic target of rapamycin kinase | 441 | 31 | 386 |
| TP53 | tumor protein p53 | 154 | 4 | 121 |
| PIK3CA | PI3-kinase catalytic subunit alpha | 3 | 2 | 0 |
| MET | MET proto-oncogene, RTK | 16 | 1 | 9 |
| FAT1 | FAT atypical cadherin 1 | 0 | 0 | 0 |
| NF2 | neurofibromin 2 | 2 | 0 | 0 |
| KDM6A | lysine demethylase 6A | 3 | 0 | 0 |
| SMARCB1 | SWI/SNF related | 1 | 0 | 0 |
| NFE2L2 | nuclear factor, erythroid 2 like 2 | 2 | 0 | 1 |
| STAG2 | stromal antigen 2 | 0 | 0 | 0 |