Table 4.
KIRC Tumor Edges Associated with Co-Occuring VHL and PBRM1 Mutations.
| GeneA | GeneB | GeneA Description | GeneB Description | Module | Notes |
|---|---|---|---|---|---|
| ENSG00000160185;UBASH3A | ENSG00000153283;CD96 | ubiquitin associated and SH3 domain containing A | CD96 molecule | TM0023 | &,‡,†,* |
| ENSG00000183918;SH2D1A | ENSG00000160185;UBASH3A | SH2 domain containing 1A | ubiquitin associated and SH3 domain containing A | TM0023 | %,‡,†,* |
| ENSG00000162739;SLAMF6 | ENSG00000160185;UBASH3A | SLAM family member 6 | ubiquitin associated and SH3 domain containing A | TM0023 | &,‡,†,* |
| ENSG00000160185;UBASH3A | ENSG00000101082;SLA2 | ubiquitin associated and SH3 domain containing A | Src like adaptor 2 | TM0023 | &,‡,†,* |
| ENSG00000160185;UBASH3A | ENSG00000116824;CD2 | ubiquitin associated and SH3 domain containing A | CD2 molecule | TM0021 | &,‡,†,* |
| ENSG00000160185;UBASH3A | ENSG00000089012;SIRPG | ubiquitin associated and SH3 domain containing A | signal regulatory protein gamma | TM0021 | &,‡,†,* |
| ENSG00000277734;TRAC | ENSG00000160185;UBASH3A | T cell receptor alpha constant | ubiquitin associated and SH3 domain containing A | TM0021 | &,‡,†,* |
| ENSG00000160185;UBASH3A | ENSG00000137078;SIT1 | ubiquitin associated and SH3 domain containing A | signaling threshold regulating transmembrane adaptor 1 | TM0021 | &,‡,†,* |
| ENSG00000160185;UBASH3A | ENSG00000147168;IL2RG | ubiquitin associated and SH3 domain containing A | interleukin 2 receptor subunit gamma | TM0021 | &,‡,†,* |
| ENSG00000167286;CD3D | ENSG00000160185;UBASH3A | CD3d molecule | ubiquitin associated and SH3 domain containing A | TM0021 | &,‡,†,* |
| ENSG00000182866;LCK | ENSG00000160185;UBASH3A | LCK proto-oncogene, Src family tyrosine kinase | ubiquitin associated and SH3 domain containing A | TM0021 | &,‡,†,* |
| ENSG00000198851;CD3E | ENSG00000160185;UBASH3A | CD3e molecule | ubiquitin associated and SH3 domain containing A | TM0021 | &,‡,†,* |
| ENSG00000163564;PYHIN1 | ENSG00000160185;UBASH3A | pyrin and HIN domain family member 1 | ubiquitin associated and SH3 domain containing A | NA | &,‡,†,* |
| ENSG00000231890;DARS-AS1 | ENSG00000227191;TCRGC2 | DARS antisense RNA 1 | T Cell Receptor Gamma Constant 2 | NA | &,‡,†,* |
| ENSG00000281881;SPRY4-IT1 | ENSG00000109920;FNBP4 | SPRY4 intronic transcript 1 | formin binding protein 4 | NA | &,‡,†,* |
| ENSG00000161405;IKZF3 | ENSG00000160185;UBASH3A | IKAROS family zinc finger 3 | ubiquitin associated and SH3 domain containing A | NA | &,‡,†,* |
| ENSG00000160185;UBASH3A | ENSG00000143851;PTPN7 | ubiquitin associated and SH3 domain containing A | protein tyrosine phosphatase, non-receptor type 7 | NA | &,‡,†,* |
| ENSG00000160185;UBASH3A | ENSG00000104814;MAP4K1 | ubiquitin associated and SH3 domain containing A | mitogen-activated protein kinase kinase kinase kinase 1 | NA | &,‡,†,* |
| ENSG00000160185;UBASH3A | ENSG00000005844;ITGAL | ubiquitin associated and SH3 domain containing A | integrin subunit alpha L | NA | &,‡,†,* |
| ENSG00000263970;RP11-789C17.5 | ENSG00000054148;PHPT1 | Antisense RNA | phosphohistidine phosphatase 1 | NA | &,‡,†,* |
| ENSG00000272505;RP11-981G7.6 | ENSG00000253641;LINCR-0001 | lincRNA | uncharacterized LINCR-0001 | NA | &,‡,†,* |
| ENSG00000234290;AC116366.6 | ENSG00000197536;C5orf56 | Antisense RNA | chromosome 5 open reading frame 56 | NA | &,‡,†,* |
| ENSG00000237721;AF064858.3 | ENSG00000235888;AF064858.1 | lincRNA | lincRNA | NA | &,‡,†,* |
| ENSG00000231233;CCDC147-AS1 | ENSG00000184277;TM2D3 | CCDC147 antisense RNA 1 | TM2 domain containing 3 | NA | &,‡,†,* |
| ENSG00000251320;AC011352.3 | ENSG00000248362;AC011352.1 | lncRNA | lncRNA | NA | &,‡,†,* |
| ENSG00000218227;RPL19P9 | ENSG00000204677;FAM153C | Ribosomal Protein L19 Pseudogene 9 | family with sequence similarity 153 member C | NA | &,‡,†,* |
| ENSG00000237471;AC073115.2 | ENSG00000229628;AC073115.7 | lincRNA | lincRNA | NA | &,‡,†,* |
&Spearman Correlation > 0.80; %Spearman Correlation < −0.80; ‡Padj KIRC Patient < 0.001; †Padj Primary Tumor < 0.001; *Padj VHL and PBRM1 Mutations < 0.001.