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. 2019 Feb 27;9:2965. doi: 10.1038/s41598-019-39182-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Immunohistochemistry showing the tissue expression of selected proteins in archived normal, KC and non-KC corneal specimens. (A) Hematoxylin-eosin images of KC and normal corneas. (B) Strong nuclear signal (arrowheads) of NDUFB11 was detected in KC epithelia (labeled E) but faint in non-KC and normal cornea. STEAP4 metalloproteinase was faintly stained in KC stroma (labelled S) than in normal corneal stroma. ADH7 was clearly detected in KC non-cone stroma (arrowheads), and was less in cone stroma. Negligible expression was found in normal and non-KC corneal stroma. IL1RN was mildly expressed in KC and non-KC stroma but faint in normal cornea. (C) Western blotting of ADH7 in KC and normal stromal fractions. (D) Band densitometry showed ADH7 was upregulated in KC non-cone than in cone stromal fractions. Normal corneal stromal samples had reduced expression. Full-length gel images are shown in Supplemental Fig. S4.