Table 3.

Differentially expressed KC stromal protein from pairwise cone versus non-cone comparison.

	UniPro Accession No.	Protein Symbol	Protein name	Mean fold changes	SD	CV	p
( A ) Upregulated stromal proteins
1	P26639	SYTC	Threonyl-tRNA synthetase	12.22	6.32	2.75	0.021*
2	Q9Y230	RUVBL2	RuvB like AAA ATPase 2	11.56	5.18	1.75	0.025*
3	P52597	HNRPF	Heterogeneous nuclear ribonucleoprotein F	8.72	8.77	1.01	0.156
4	Q15293	RCN1	Reticulocalbin 1	8.38	5.82	0.92	0.185
5	Q04828	AK1C1	Aldo-keto reductase family 1 member C1	7.79	5.32	1.63	0.214
6	O43504	LTOR5	Late endosomal/lysosomal adaptor, MAPK And MTOR activator 5	6.71	4.22	1.08	0.130
7	P27169	PON1	Paraoxonase 1	4.94	3.81	0.77	0.230
8	P01714	IGLV3-19	Immunoglobulin lambda variable 3-19	4.83	7.06	1.46	0.250
9	O43396	TXNL1	Thioredoxin like 1	4.29	2.85	0.88	0.292
10	Q9UK76	HN1	Hematological and neurological expressed 1	3.75	3.28	0.99	0.109
11	P01602	IGKV1-5	Immunoglobulin kappa variable 1–5	3.17	2.03	0.64	0.056
12	P0CG06	LAC3	Immunoglobulin lambda constant 3 (Kern-Oz + Marker)	3.02	2.17	0.79	0.091
13	O60763	USO1	USO1 vesicle transport factor	2.84	2.33	0.82	0.093
14	P14780	MMP9	Matrix metalloproteinase 9	2.38	0.97	0.41	0.251
( B ) Downregulated stromal proteins
1	P09758	TACSTD2	Tumor-associated calcium signal transducer 2	0.32	0.14	0.55	0.006*
2	P34896	SHMT1	Serine hydroxymethyl transferase 1	0.32	0.31	0.98	0.088
3	Q9NTK5	OLA1	Obg like ATPase 1	0.32	0.28	0.88	0.053
4	Q9H0W9	C11orf54	Chromosome 11 open reading frame 54	0.34	0.32	0.93	0.092
5	Q6UXI7	VIT	Vitrin	0.35	0.09	0.55	0.047*
6	P11166	SLC2A1	Solute carrier family 2 member 1	0.39	0.42	1.06	0.131
7	O95342	ABCB11	ATP binding cassette subfamily B11	0.4	0.14	0.36	0.017*
8	Q9NR31	SAR1A	Secretion associated Ras related GTPase 1A	0.4	0.23	0.58	0.046*
9	P15559	NQO1	NAD(P)H quinone dehydrogenase 1	0.42	0.14	0.50	0.021*
10	Q9BTM1	H2AJ	H2A histone family member J	0.42	0.15	0.35	0.016*
11	Q687X5	STEAP4	STEAP4 metalloreductase	0.44	0.12	0.74	0.041*
12	P14174	MIF	Macrophage migration inhibitory factor	0.44	0.18	0.41	0.025*
13	Q15393	SF3B3	Splicing Factor 3b Subunit 3	0.44	0.25	0.56	0.042*
14	P18510	IL1RN	Interleukin 1 receptor agonist	0.44	0.36	0.81	0.068
15	P62318	SMD3	Small nuclear ribonucleoprotein D3 polypeptide	0.46	0.37	0.82	0.171
16	O43175	PHGDH	Phosphoglycerate dehydrogenase	0.47	0.25	0.70	0.035*
17	Q7L1Q6	BZW1	Basic leucine zipper and W2 domain 1	0.47	0.23	0.48	0.047*
18	Q9BTV4	TMM43	Transmembrane protein 43	0.48	0.35	0.73	0.091
19	P55769	NH2L1	SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)	0.48	0.34	0.59	0.086
20	P40394	ADH7	Alcohol dehydrogenase 7 (Class IV), Mu Or Sigma polypeptide	0.49	0.01	0.35	0.016*
21	P23800	LOX	Lysyl oxidase	0.49	0.24	1.88	0.276
22	P21796	VDAC1	Voltage dependent anion channel 1	0.49	0.36	0.72	0.217

These proteins had same changes in all 4 KC sample pairs. Note: Mean fold changes from all 4 KC sample pairs; SD – standard deviation; CV: coefficient of variation; p: significance value (paired Student’s t-test; *p < 0.05 denotes statistical significance).