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. 2018 Dec 28;294(8):2700–2713. doi: 10.1074/jbc.RA118.007095

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© 2019 Robinett et al.

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Figure 4. — Targeted screen of metal chelators as inhibitors of copper-only SOD5. A, list of known metal chelators tested for reactivity with Cu,Zn-SOD1 and copper-only SOD5. Preferred Metal Ion(s), metal selectivity as previously published: TETA (53, 54), DPEN (54), CQ (54, 55), NEO (54, 56), TTM (49), DFO (57), DFZ (58), BPS (59), BCS (54, 59), DTPA (59), EDTA (54), and DETC (54). Avg % Inh, average percent inhibition of copper-only SOD5 and Cu,Zn-SOD1 with 10 μm compound as described in the legend to Fig. 3. Values are averages of two independent experimental trials with S.D. –, no detectable inhibition. B, structure of chelators showing selective inhibition of copper-only SOD5.