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. 2019 Jan 2;294(8):2628–2641. doi: 10.1074/jbc.RA118.005477

Figure 9.

Figure 9.

Schematic illustration of the mechanisms underlying the immunopotentiating effect of the proteoglycan TPG-1 from Huaier. TPG-1 exerted anti-tumor activity partially through the immunopotentiating effect that resulted from up-regulation of TNFα, IL-6, and NO, mediated by TLR4-dependent activation of NF-κB and MAPK signaling pathways.