Figure 7.

Schematic of Grx1 and ROS involvement in neutrophil mobilization from the bone marrow via integrin α4/VCAM-1. Under stress conditions, the level of ROS is elevated in the bone marrow microenvironment. ROS induced the glutathionylation of α4 integrin in neutrophils, which increased the affinity of α4 of neutrophils to VCAM-1 on endothelial cells in the bone marrow. Furthermore, glutathionylation of α4 promoted neutrophil mobilization from the bone marrow. These effects were negatively mediated by Grx1.