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. 2018 Dec 26;294(8):2935–2946. doi: 10.1074/jbc.RA118.005504

Figure 3.

Figure 3.

2-Hydroxyestrone (2HE1) increases insulin secretion and induces calcium influx in INS-1 cells. A, stimulation of insulin secretion with increasing concentrations of 2HE1 in INS-1 cells (n = 6). **, p < 0.01; and ***, p < 0.001 versus insulin secretion in the vehicle group. B, cytosolic free Ca2+ responses to increasing concentrations of 2HE1 in INS-1 cells (n = 3). Dotted lines depict S.E. values. C, concentration–response curve constructed from experiments shown in B for the average area-under-the-curve (AUC) values for Ca2+ responses to 2HE1 (n = 3).