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. 2018 Dec 21;294(8):2854–2861. doi: 10.1074/jbc.RA118.006546

Figure 2.

Figure 2.

Sequence analysis of R. palustris PIMTs. A, sequence similarity network of all protein sequences containing the PIMT Pfam domain PF01135. Group I, which contains RPA0376 and RPA2838, includes only bacterial and archaeal PIMTs. Group II contains only eukaryotic PIMTs. Group III containing RPA2580 has ∼700 sequences, all of which come from α-proteobacteria. B, a predicted structure of RPA2580 (red) threaded onto the structure of P. furiosus PIMT (black; Protein Data Bank code 1JG3). S-Adenosyl homoserine is shown in yellow, and the peptide VYP-isoD-HA is shown in cyan. The arrow points to the loop that is present in the predicted structure of RPA2580 that does not align with the P. furiosus structure.