Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Dec 19;294(8):2892–2902. doi: 10.1074/jbc.RA118.006764

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Loerch et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

Figure 6. — Tat-SF1 UHM-SF3b1 ULM interactions. A, ULM4 and B, ULM5. Hydrogen bonds are indicated by dashed lines. Key interacting residues are labeled; SF3b1 residues are italicized. Packing interactions are indicated by semitransparent surfaces. Isothermal titration calorimetry confirms structure-guided mutations of the Tat-SF1 interface abolish detectable binding to SF3b1 ULMs. Representative isotherms for: C, E286K/D290K or D, E286K/F337A mutant Tat-SF1 (residues 1–360) titrated with SF3b1 ULM5 are shown.