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. 2018 Dec 20;294(8):2924–2934. doi: 10.1074/jbc.RA118.005471

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© 2019 Sulistomo et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 1. — Fhod3 expression in rhombomeres 1–6 within the hindbrain. A, schematic representation of the cranial neural tube closure in mouse embryos. Closure I occurs from the hindbrain/spinal boundary (red asterisk) and proceeds bidirectionally. Closures II and III begin at the forebrain/midbrain boundary and the rostral end of the neural plate, respectively (green asterisks). By E9.5, the caudally directed closure II/III meets the rostrally directed closure I to seal the midbrain-hindbrain region. For details, see the Result section. Fhod3 is expressed in the heart and rhombomeres within the hindbrain region (green) during the neural tube closure. Fore, forebrain; Mid, midbrain; Hind, hindbrain. B, whole-mount nuclear fluorescent staining of Fhod3^+/+ (+/+) and Fhod3^−/− (−/−) embryos at E9.5. The open regions of the cranial neural tube are indicated by magenta dotted lines. Scale bar, 500 μm. C and D, whole-mount lacZ staining of Fhod3^+/+, Fhod3^+/−, and Fhod3^−/− embryos at E9.5. Open and closed regions are indicated by magenta and green dotted lines, respectively. R1–6, rhombomeres 1–6; ov, otic vesicle. Scale bars, 500 μm.