Table 1.
Association of gene expression (high level) with tumor stage, lymph node, age, gender, and smoking in 516 patients with lung adenocarcinoma (LUAD)
| Stage | N = 508 | ADH1B | AGER | CCNB1 | CENPU | CLIC5 | FAM189A2 | GOLM1 | GPM6A |
|---|---|---|---|---|---|---|---|---|---|
| I | 277 | 157 (56.7) | 154 (55.6) | 117 (47.2) | 123 (44.4) | 159 (57.4) | 159 (57.4) | 126 (45.5) | 153 (55.2) |
| II | 122 | 52 (42.6) | 53 (43.4) | 71 (58.2) | 70 (57.4) | 56 (45.9) | 53 (43.4) | 69 (56.6) | 56 (45.9) |
| III | 84 | 31 (36.9) | 34 (40.5) | 53 (63.1) | 47 (56.0) | 29 (34.5) | 33 (39.3) | 50 (59.5) | 31 (36.9) |
| IV | 25 | 12 (48.0) | 12 (48.0) | 14 (56.0) | 15 (60.0) | 9 (36.0) | 8 (32.0) | 10 (40.0) | 12 (48.0) |
| p | 0.004 | 0.034 | 0.001 | 0.040 | 0.001 | 0.002 | 0.039 | 0.022 | |
| Lymph node | N = 515 | ADH1B | CCNB1 | CENPU | CLIC5 | COL11A1 | FAM189A2 | TMEM106B | |
| 0 | 333 | 181 (54.4) | 148 (44.4) | 155 (46.5) | 182 (54.7) | 155 (46.5) | 182 (54.7) | 150 (45.0) | |
| ≥1 | 182 | 76 (41.8) | 110 (60.4) | 103 (56.6) | 75 (41.2) | 104 (57.1) | 75 (41.2) | 108 (59.3) | |
| p | 0.006 | 0.001 | 0.029 | 0.004 | 0.022 | 0.004 | 0.002 | ||
| Gender | N = 516 | ADH1B | CCNB1 | CENPU | FAM107A | HMGB3 | SLIT3 | SRPK1 | TNXB |
| Male | 239 | 107 (44.8) | 135 (56.5) | 134 (56.1) | 104 (43.5) | 136 (56.9) | 108 (45.2) | 135 (56.5) | 101 (42.3) |
| Female | 277 | 151 (54.5) | 123 (44.4) | 124 (44.8) | 154 (55.6) | 123 (44.4) | 151 (54.5) | 124 (44.8) | 157 (56.7) |
| p | 0.027 | 0.006 | 0.010 | 0.006 | 0.005 | 0.035 | 0.008 | 0.001 | |
| Age | N = 497 | ADH1B | CCNB1 | CENPU | CLIC5 | GPM6A | |||
| <65 | 221 | 94 (42.5) | 123 (55.7) | 125 (56.6) | 86 (38.9) | 95 (43.0) | |||
| ≥65 | 276 | 155 (56.2) | 122 (44.2) | 120 (43.5) | 159 (57.6) | 151 (54.7) | |||
| p | 0.003 | 0.011 | 0.004 | 0.000 | 0.009 | ||||
| Smoking | N = 349 | ADAMSTL | CENPU | EDNRB | FAM107A | TGFBR3 | TMEM106B | ||
| <40 pack‐year | 172 | 93 (54.1) | 77 (44.8) | 98 (57.0) | 98 (57.0) | 88 (51.2) | 65 (37.8) | ||
| ≥40 pack‐year | 177 | 76 (42.9) | 107 (60.5) | 76 (42.9) | 81 (45.8) | 69 (39.0) | 92 (52.0) | ||
| p | 0.037 | 0.003 | 0.009 | 0.036 | 0.022 | 0.008 |
p: chi‐square test.