Table 2.
Basic information of candidate SNPs and associations with LDD risk
| SNP | Gene | Chr | Alle (A/B) | MAF (case) | MAF (control) | HWE (p) | OR | 95%CI | p |
|---|---|---|---|---|---|---|---|---|---|
| rs756441 | COL11A2 | 6 | A/G | 0.445 | 0.436 | 0.756 | 1.04 | 0.85–1.27 | 0.714 |
| rs17214944 | COL11A2 | 6 | G/A | 0.081 | 0.052 | 0.613 | 1.60 | 1.06–2.41 | 0.204 |
| rs3129207 | COL11A2 | 6 | C/G | 0.529 | 0.496 | 0.838 | 1.14 | 0.93–1.39 | 0.202 |
| rs9380350 | COL11A2 | 6 | T/C | 0.413 | 0.439 | 0.918 | 0.90 | 0.73–1.10 | 0.298 |
| rs986522 | COL11A2 | 6 | C/G | 0.217 | 0.197 | 0.014 | 1.14 | 0.89–1.45 | 0.314 |
| rs2071025 | COL11A2 | 6 | A/G | 0.471 | 0.378 | 0.914 | 1.47 | 1.20–1.80 | 0.0002* |
CI: confidence interval; HWE: Hardy–Weinberg equilibrium; MAF: minor allele frequency; OR: odds ratio; SNPs: single‐nucleotide polymorphisms.
p‐value was calculated by Pearson's chi‐square test.
*p‐value <0.05 indicates statistical significance.