Table 5.
Genotypic model analysis of relationship between SNPs and LDD risk by gender stratification
| SNP | Model | Genotype | Male | Female | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Control | Case | OR (95% CI) | p‐value | Control | Case | OR (95% CI) | p‐value | |||
| rs986522 | Codominant | G/G | 141 (63%) | 134 (58.8%) | 1 | 0.52 | 99 (61.9%) | 101 (64.7%) | 1 | 0.019* |
| C/G | 78 (34.8%) | 86 (37.7%) | 1.16 (0.79–1.72) | 59 (36.9%) | 45 (28.9%) | 0.74 (0.46–1.20) | ||||
| C/C | 5 (2.2%) | 8 (3.5%) | 1.73 (0.55–5.48) | 2 (1.2%) | 10 (6.4%) | 5.10 (1.07–24.18) | ||||
| Dominant | G/G | 141 (63%) | 134 (58.8%) | 1 | 0.35 | 99 (61.9%) | 101 (64.7%) | 1 | 0.58 | |
| C/G‐C/C | 83 (37%) | 94 (41.2%) | 1.20 (0.82–1.75) | 61 (38.1%) | 55 (35.3%) | 0.88 (0.55–1.40) | ||||
| Recessive | G/G‐C/G | 219 (97.8%) | 220 (96.5%) | 1 | 0.39 | 158 (98.8%) | 146 (93.6%) | 1 | 0.011* | |
| C/C | 5 (2.2%) | 8 (3.5%) | 1.64 (0.52–5.13) | 2 (1.2%) | 10 (6.4%) | 5.65 (1.20–26.56) | ||||
| Log‐additive | – | – | – | 1.21 (0.86–1.70) | 0.28 | – | – | 1.07 (0.72–1.60) | 0.72 | |
| rs2071025 | Codominant | G/G | 85 (38%) | 63 (27.6%) | 1 | 0.028* | 63 (39.4%) | 52 (33.3%) | 1 | 0.0036* |
| G/A | 99 (44.2%) | 106 (46.5%) | 1.49 (0.97–2.29) | 83 (51.9%) | 70 (44.9%) | 1.01 (0.62–1.65) | ||||
| A/A | 40 (17.9%) | 59 (25.9%) | 1.98 (1.18–3.34) | 14 (8.8%) | 34 (21.8%) | 3.05 (1.46–6.36) | ||||
| Dominant | G/G | 85 (38%) | 63 (27.6%) | 1 | 0.016* | 63 (39.4%) | 52 (33.3%) | 1 | 0.27 | |
| G/A‐A/A | 139 (62%) | 165 (72.4%) | 1.63 (1.09–2.44) | 97 (60.6%) | 104 (66.7%) | 1.30 (0.81–2.07) | ||||
| Recessive | G/G‐G/A | 184 (82.1%) | 169 (74.1%) | 1 | 0.052 | 146 (91.2%) | 122 (78.2%) | 1 | 8.00E−04* | |
| A/A | 40 (17.9%) | 59 (25.9%) | 1.57 (0.99–2.48) | 14 (8.8%) | 34 (21.8%) | 3.03 (1.54–5.97) | ||||
| Log‐additive | – | – | – | 1.42 (1.09–1.83) | 0.008* | – | – | 1.52 (1.09–2.12) | 0.012* | |
CI: confidence interval; OR: odds ratio; SNPs: single‐nucleotide polymorphisms.
*P‐value <0.05 indicates statistical significance.