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. 2019 Feb 27;9:2953. doi: 10.1038/s41598-019-39007-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of Alox15 as a specific marker for Ly6C^loCX₃CR1^hi macrophages. (A) Western blot analysis for Alox15 expression in 24 h Ly6C^hiCX₃CR1^lo and 72 h Ly6C^loCX₃CR1^hi macrophages. Full-length blots are shown in Fig. S3C. (B) Flow cytometric analysis for Alox15 expression in 24 h Ly6C^hiCX₃CR1^lo and 72 h Ly6C^loCX₃CR1^hi macrophages. Cell populations from five mice were pooled to form one group. (C) Alox15⁺CX₃CR1^hi macrophages were in close proximity to proliferating hepatocytes. White arrows indicate proliferating hepatocytes labeled with Ki67, and arrowheads indicate macrophages labeled with F4/80 and Alox15 in WT mice (upper panel) or F4/80 in Cx3cr1^GFP/+ mice (lower panel). Scale bars, 20μm. Data shown are representative of three independent experiments.