Table 1.
Patients’ and disease characteristics, overall and according to ATM mutational status.
| Characteristics | Total (N = 227) N (%) |
ATM mut (N = 35) N (%) |
ATM wt (N = 192) N (%) |
P* | |
|---|---|---|---|---|---|
| Age (years) | <65 ≥65 |
147 (65) 80 (35) |
25 (71) 10 (29) |
122 (64) 70 (36) |
0.40 |
| Gender | Male Female |
93 (41) 134 (59) |
17 (49) 18 (51) |
76 (40) 116 (60) |
0.32 |
| ECOG PS | 0 1–2 NA |
197 (92) 18 (8) 12 |
34 (97) 1(3) 0 |
163 (91) 17 (9) 12 |
0.20 |
| Primary tumor location | Left-sided Right-sided |
159 (70) 68 (30) |
27 (77) 8 (23) |
132 (69) 60 (31) |
0.32 |
| Primary tumor resection | Yes No |
192 (85) 35 (15) |
31 (89) 4 (11) |
161 (84) 31 (16) |
0.48 |
| Synchronous mets | No Yes |
67 (30) 160 (70) |
13 (37) 22 (63) |
54 (28) 138 (72) |
0.28 |
| Metastatic sites (N) | 1> 1 |
135 (59) 92 (41) |
24 (69) 11 (31) |
111 (58) 81 (42) |
0.23 |
| All-RAS status | Wild-type Mutated |
127 (56) 100 (44) |
20 (57) 15 (43) |
107 (56) 85 (44) |
0.88 |
| BRAF status | Wild-type Mutated |
214 (94) 13 (6) |
33 (94) 2 (6) |
181 (94) 11 (6) |
0.99 |
| MSI status | MSS MSI NA |
188 (94) 13 (6) 26 |
26 (87) 4 (13) 5 |
162 (95) 9 (5) 21 |
0.11 |
*Chi-square test or Fisher exact test, as appropriate.
Abbreviations. ECOG PS: Eastern Cooperative Oncology Group Performance Status. MSI: microsatellite instability. MSS: microsatellite stability. Mut: mutated. Wt: wild-type.