Table 3.
Univariate and multivariate analyses for overall survival.
| Characteristics | Univariate analyses | Multivariable model | |||
|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | ||
| Age (years) | ≥65 vs <65 | 1.60 (1.10–2.20) | 0.009 | — | 0.25 |
| Gender | Female vs Male | — | 0.24 | — | — |
| ECOG PS | 1–2 vs 0 | — | 0.15 | — | — |
| Primary tumor location | Right vs Left | 2.00 (1.40–2.80) | <0.001 | 1.70 (1.17–2.46) | 0.005 |
| Primary tumor resection | No vs Yes | 1.90 (1.20–2.90) | 0.005 | 1.62 (1.04–2.54) | 0.03 |
| Synchronous mets | Yes vs No | 1.80 (1.20–2.60) | 0.003 | 1.76 (1.19–2.61) | 0.005 |
| Metastatic sites (N) | >1 vs 1 | 1.70 (1.20–2.40) | 0.002 | 1.47 (1.03–2.08) | 0.03 |
| All-RAS status | Mut vs wt | — | 0.06 | — | — |
| BRAF status | Mut vs wt | 2.10 (1.10–4.00) | 0.03 | — | 0.09 |
| MSI status | MSI vs MSS | — | 0.16 | — | — |
| ATM status | Mut vs wt | 0.50 (0.29–0.85) | 0.01 | 0.57 (0.33–0.98) | 0.04 |
Abbreviations. ECOG PS: Eastern Cooperative Oncology Group Performance Status. Mets: metastases. MSI: microsatellite instability. MSS: microsatellite stable. Mut: mutated. Wt: wild-type.