Figure 2.

The Effects of PPFIA1 or miR-181a on the Malignant Progression of CML

(A) Downregulation of PPFIA1 by transfecting with PPFIA1-siRNA and miR-181a mimics increased the sensitivities of STI571 in K562 cells. (B) Downregulation of PPFIA1 inhibited the invasion ability in K562 cells. (C) Downregulation of PPFIA1 by targeting PPFIA1-siRNA or miR-181a mimics inhibited the colony-formation ability in K562 cells. (D) Overexpression of PPFIA1 decreased the sensitivities of STI571 in K562 cells. (E) Overexpression of PPFIA1 promotes the invasion ability in K562 cells. (F) Overexpression of PPFIA1 promotes the colony-formation ability in K562 cells. The data were presented as the mean ± SD obtained from at least three independent experiments. Significance was determined by Student’s t test, *p < 0.05 versus NC control or empty vector.