Figure 2.

Interfacing plant alkaloid secondary metabolic pathways with microbial metabolism. S. cerevisiae is shown as the prospective host species. Refer to Figure 1 for abbreviations and color coding. Additional abbreviations: AAA path, aromatic amino acid pathway; Aro1, pentafunctional arom protein; Aro2, chorismate synthase and Flavin reductase; Aro3+Aro4, 3-deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) synthase isoenzymes; Aro7, chorismate mutase; E4P, erythrose 4-phosphate; 4-HPAA, 4-hydroxyphenylacetaldehyde; PPP, pentose phosphate pathway; PEP, phosphoenolpyruvate; R5P, ribose 5-phosphate; TCA cycle, tricarboxylic acid cycle.