Table 1. Selection of de novo plant secondary pathway reconstructions in microbial systems.

ND, no data available; NR, titer not reported.

Metabolite class	Metabolite	Titer (mg/L)		Reference(s)
		S. cerevisiae	E. coli
PRECURSORS	Tyr	1,930a	55,000	(Patnaik et al., 2008)
	p-coumaric acid	1,930	2,510	(Rodriguez et al., 2015; Jones et al., 2017)
	dopamine	24	2,150	(Nakagawa et al., 2014; DeLoache et al., 2015)
TERPENOIDS	Monoterpenoids
	geraniol	1,680	2,000	(Liu et al., 2016; Jiang et al., 2017)
	pinene	ND	970	(Yang et al., 2013)
	limonene	0.49	2,700	(Willrodt et al., 2014; Jongedijk et al., 2015)
	eucalyptol	400	653	(Ignea et al., 2011; Mendez-Perez et al., 2017)
	linalool	0.75	505	(Mendez-Perez et al., 2017; Camesasca et al., 2018)
	Sesquiterpenoids
	β-farnesene	130,000	8,700	(Meadows et al., 2016; You et al., 2017)
	bisabolene	5,200	912	(Peralta-Yahya et al., 2011; Özaydin et al., 2013)
	α-humulene	1,300	ND	(Zhang et al., 2018b)
	β-caryophyllene	ND	1,520	(Yang et al., 2016)
	amorphadiene	37,000	27,400	(Tsuruta et al., 2009; Westfall et al., 2012)
	artemisinic acid	25,000	ND	(Paddon et al., 2013)
	santalene	163	ND	(Tippmann et al., 2016)
	patchoulol	40.9	ND	(Albertsen et al., 2011)
	Diterpenoids
	jolkinol C	800	ND	(Wong et al., 2018)
	taxadiene	72.8	1,020	(Ajikumar et al., 2010; Ding et al., 2014)
	Triterpenoids
	β-amyrin	108.1	NR	(Takemura et al., 2017; Zhu et al., 2018)
	Tetraterpenoids
	β-carotene	162.1	3,200	(Yang and Guo, 2014; Wang et al., 2016)
	lycopene	1,650	3,520	(Sun et al., 2014; Chen et al., 2016)
ALKALOIDS	Benzylisoquinoline alkaloids
	(S)-reticuline	0.082	160	(DeLoache et al., 2015; Matsumura et al., 2018)
	thebaine	0.0064	2.1	(Galanie et al., 2015; Nakagawa et al., 2016)
	hydrocodone	0.0003	0.36	(Galanie et al., 2015; Nakagawa et al., 2016)
	noscapine	2.2	ND	(Li et al., 2018)
	Monoterpene indole alkaloids
	strictosidine	0.5	ND	(Brown et al., 2015)
PHENYLPROPANOIDS	Stilbenoids
	resveratrol	>5,000	51.8	(Katz et al., 2013; Yang et al., 2018)
	pinostilbene	5.52	∼2.5	(Kang et al., 2014; Li et al., 2016b)
	pterostilbene	34.93	33.6	(Li et al., 2016b; Heo et al., 2017)
	pinosylvin	130.02	281	(Katz et al., 2008; Wu et al., 2017)
	Flavonoids
	naringenin	>200	103.8	(Lehka et al., 2017; Yang et al., 2018)
	scutellarin	108	ND	(Liu et al., 2018)
	genistein	7.7	ND	(Trantas et al., 2009)
	pinocembrin	2.6	525.8	(Wu et al., 2016b; Eichenberger et al., 2017)
	quercetin	20.38	ND	(Rodriguez et al., 2017)
	kaempferol	66.29	57b	(Yang et al., 2014; Duan et al., 2017)
	dihydrokaempferol	44	ND	(Levisson et al., 2018)
	pelargonidin-3-O-glucoside	0.02	9.5	(Jones et al., 2017; Levisson et al., 2018)
	phloretin	42.7	ND	(Eichenberger et al., 2017)
	Coumarins
	umbelliferone	ND	66.1	(Yang et al., 2015a)
	esculetin	ND	61.4	(Yang et al., 2015a)
	4-hydroxycoumarin	ND	483.1	(Lin et al., 2013)

^aTiter reported for the downstream metabolite p-coumaric acid.

^bTiter reported for kaempferol 3-O-rhamnoside.