Table 2.
Multivariate analysis of factors associated with DC, DRS and CPS with the factors: ethnicity, employment, treatment status, cohort, MS type and treatment potency.
| Factor | Odds ratio (95%CI upper, lower), p |
||||
|---|---|---|---|---|---|
| DC | DC with CPS instead of ethnicity | DRS | DRS with CPS instead of ethnicity | CPS | |
| Treatment status | 1.253 (1.087, 1.444), 0.002 | 1.224 (1.077, 1.437), 0.003 | 48728 (321.1, 7.7.39 × 106), 0.000 | 65248 (417.1, 1.02 × 107), 0.000 | – |
| CohortReference is c1 unknown Rx | Cohort 2. 0.841 (0.730, 0.970), 0.017Cohort 3. 0.724 (0.613, 0.855), 0.000 | Cohort 2. 0.845 (0.729, 0.979), 0.025Cohort 3. 0.724 (0.612, 0.857), 0.000 | Cohort 2. 1.6 × 10−5 (1.1 × 10−7, 0.002), 0.000Cohort 3. 0.0005 (1.2 × 10−6, 0.172), 0.011 | Cohort 2. 1.9 × 10−5 (1.1 × 10−7, 0.003), 0.000Cohort 3. 3.9 × 10−4, (1.0 × 10−6, 0.148), 0.010 | – |
| Employment | 1.173 (1.039, 1.323), 0.010 | 1.186 (1.047, 1.343), 0.007 | – | – | – |
| MS disease type | – | – | – | – | 0.612 (0.412, 0.909), 0.015 |
| Treatment Potency | 0.875 (0.800, 0.958), 0.004 | 0.872 (0.796, 0.956), 0.004 | 0.006 (0.0002, 0.157), 0.002 | 0.007 (0.0003, 0.163), 0.002 | – |
| Ethnicity | 1.192 (1.023, 1.389), 0.024 | NA | 860.093(3.837, 1.9 × 105), 0.015 | NA | 1.616 (1.210, 2.156), 0.001 |
| CPS | NA | 1.093 (1.022, 1.170), 0.010 | NA | 77.67 (7.089, 851), 0.0004 | NA |
DC (column 1) was associated with less satisfaction with treatment, being part of the ‘MS conference attendees’ cohort, being of non-white ethnicity, being in employment and on a less potent treatment. High levels of decisional regret (column 3) was associated with being less satisfied with treatment, being part of the ‘MS conference attendees’ cohort, being of non-white ethnicity and being on a less potent treatment. Higher CPS (column 5), e.g. more passivity in decision-making, was associated with non-white ethnicity and RRMS phenotype. When CPS replaced ethnicity as a variable it was then significant in the model (DC - column 2; DRS – column 4)