Figure 3. 5-fluorouracil (5-FU) induced macroscopic and microscopic injury, which was prevented by amifostine. The saline-treated and scratch groups showed no sign of tissue damage. Conversely, 5-FU significantly induced tissue erythema, mucosal ulceration, abscesses, and hemorrhage versus the saline group. In addition, amifostine (AMF) protected the animals from the macroscopic and microscopic damage compared to the 5-FU group. Arrowheads indicate areas of inflammatory infiltration. Arrows denote edema and ulceration areas. Magnification: 40×, scale bar: 500 μm.
