Figure 4. 5-fluorouracil (5-FU)-induced inflammation was abolished in amifostine-treated animals. The proinflammatory effect of 5-FU upon the cheek pouch was detected as an increase in myeloperoxidase activity (A) and the production of tumor necrosis factor-alpha (TNF-α) (B) and interleukin-1 beta (IL-1β) (C). Data are reported as means±SE (n=6/group). *P<0.05, **P<0.01 vs group treated only with saline or scratch. #P<0.05 vs 5-FU-treated group.
