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The protective effects of RGFP966 were mediated by the upregulation of Bmal1. Representative Western blot images and assessment of the HDAC3 and Bmal1 level in each group. HDAC3 and Bmal1 expression in the mouse brain (a, b) and HDAC3 and Bmal1 expression in PC12 cells (c, d). All results are presented as mean ± SD, n = 6/group. #P < 0.05 versus the DS group, △P < 0.05 versus the DIR group, ∗P < 0.05 versus the HG group, and &P < 0.05 versus the HH/R group.
