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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Am J Transplant. 2018 Sep 24;19(3):674–685. doi: 10.1111/ajt.15087

Figure 1. Recipient deficiency in MerTK impairs transplantation tolerance.

Figure 1.

A full MHC-mismatched BALB/c to B6 islet (A) or heart (B) transplant model was used. B6 recipients were either Mertk+/+ or Mertk−/−. Recipients were either untreated or injected with BALB/c or third party (C3H) ECDI-SP on day-7 and day+1. Transplant was performed on day 0. Graft survival was determined as described in Methods. (A-B) Statistical significance was determined using Log-rank (Mantel-Cox) test. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.