Table 3.
Histologic classification of IgA nephropathy of Haas (according to ref. [29])
Haas classification | Description |
---|---|
Class I – Minimal histologic lesion | Glomeruli are normocellular, without segmental sclerosis, necrosis, or crescents. |
Class II – Focal-segmental glomerulosclerosis (FSGS)-like | Glomeruli show focal and segmental sclerosis without mesangial or endocapillary hypercellularity, crescents, or necrosis. |
Class III – Focal proliferative glomerulonephritis | 50% or fewer of the glomeruli (not including globally sclerotic glomeruli) are hypercellular. This hypercellularity may be limited to mesangial areas, or include endocapillary hypercellularity, crescents, or necrosis. |
Class IV – Diffuse proliferative glomerulonephritis | More than 50% of the glomeruli (not including globally sclerotic glomeruli) are hypercellular. This hypercellularity may be limited to mesangial areas, or include endocapillary hypercellularity, crescents, or necrosis. |
Class V – Advanced chronic glomerulonephritis | 40% or more of the glomeruli are globally sclerotic, and/or there is > 40% estimated tubular atrophy or loss in the cortex. If these criteria are met, the biopsy specimen is graded as class V regardless of other histologic features. |
Modified with permission from Elsevier Ltd.©