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. 2019 Feb 28;17:60. doi: 10.1186/s12967-019-1806-6

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Glycolysis pathway showing how increased PFK-2/FBPase-2 expression and phosphorylation, stimulates glycolysis via increased fructose-2,6-bisphosphate synthesis acting as a powerful allosteric activator of PFK-1. The arrows show how the changes observed in PE are predicted to increase renal glycolysis. PFK-1 phosphofructokinase 1, PFK-2/FBPase-2 6-phosphofructokinase-2-kinase/fructose-2,6-bisphosphatase, Fru 2,6-P2 fructose 2,6-bisphosphate, PEP phosphoenolpyruvate, AMPK AMP-activated protein kinase, PKA protein kinase A, PKB protein kinase B