Table 3.
Association of the selected SNPs in IL1A with CRC risk after stratified analysis by gender
| SNP_ID | Genotypes | Male | OR (95% CI) | p a | Female | OR (95% CI) | p b | ||
|---|---|---|---|---|---|---|---|---|---|
| Controls, n(%) | Patients, n(%) | Controls, n(%) | Patients, n(%) | ||||||
| rs3783550 | |||||||||
| G/G | 113 (42.6%) | 62 (43.7%) | 1.00 | 93 (47.0%) | 41 (39.0%) | 1.00 | |||
| Codominant | G/T | 123 (46.4%) | 63 (44.4%) | 0.85 (0.53–1.38) | 0.800 | 89 (45.0%) | 48 (45.7%) | 1.22 (0.73–2.04) | 0.096 |
| T/T | 29 (10.9%) | 17 (12.0%) | 0.96 (0.47–1.98) | 16 (8.1%) | 16 (15.2%) | 2.41 (1.09–5.34) | |||
| Dominant (ref: G/G) | G/T-T/T | 152 (57.4%) | 80 (56.3%) | 0.88 (0.56–1.38) | 0.560 | 105 (53.0%) | 64 (61.0%) | 1.40 (0.86–2.27) | 0.180 |
| Recessive (ref: G/G + G/T) | T/T | 29 (10.9%) | 17 (12.0%) | 1.05 (0.53–2.06) | 0.900 | 16 (8.1%) | 16 (15.2%) | 2.17 (1.03–4.60) | 0.043 |
| rs3783546 | |||||||||
| G/G | 113 (42.8%) | 62 (43.4%) | 1.00 | 93 (47.2%) | 42 (40.0%) | 1.00 | |||
| Codominant | G/C | 122 (46.2%) | 65 (45.5%) | 0.87 (0.54–1.40) | 0.850 | 88 (44.7%) | 48 (45.7%) | 1.21 (0.72–2.01) | 0.170 |
| C/C | 29 (11.0%) | 16 (11.2%) | 0.92 (0.44–1.90) | 16 (8.1%) | 15 (14.3%) | 2.18 (0.97–4.85) | |||
| Dominant (ref: G/G) | G/C-C/C | 151 (57.2%) | 81 (56.6%) | 0.88 (0.56–1.38) | 0.580 | 104 (52.8%) | 63 (60.0%) | 1.35 (0.83–2.20) | 0.220 |
| Recessive (ref: G/G + G/C) | C/C | 29 (11.0%) | 16 (11.2%) | 0.98 (0.49–1.95) | 0.960 | 16 (8.1%) | 15 (14.3%) | 1.98 (0.93–4.21) | 0.080 |
| rs2856838 | |||||||||
| G/G | 142 (54.0%) | 88 (61.5%) | 1.00 | 115 (58.1%) | 55 (52.4%) | 1.00 | |||
| Codominant | G/A | 109 (41.4%) | 47 (32.9%) | 0.68 (0.42–1.10) | 0.260 | 71 (35.9%) | 36 (34.3%) | 1.06 (0.63–1.77) | 0.078 |
| A/A | 12 (4.6%) | 8 (5.6%) | 1.07 (0.39–2.94) | 12 (6.1%) | 14 (13.3%) | 2.63 (1.13–6.15) | |||
| Dominant (ref: G/G) | G/A-A/A | 121 (46.0%) | 55 (38.5%) | 0.72 (0.46–1.14) | 0.160 | 83 (41.9%) | 50 (47.6%) | 1.27 (0.79–2.06) | 0.330 |
| Recessive (ref: G/G + G/A) | A/A | 12 (4.6%) | 8 (5.6%) | 1.24 (0.46–3.36) | 0.670 | 12 (6.1%) | 14 (13.3%) | 2.58 (1.13–5.87) | 0.024 |
| rs1609682 | |||||||||
| G/G | 113 (42.6%) | 64 (44.8%) | 1.00 | 92 (46.7%) | 41 (39.4%) | 1.00 | |||
| Codominant | G/T | 123 (46.4%) | 62 (43.4%) | 0.81 (0.50–1.30) | 0.670 | 89 (45.2%) | 47 (45.2%) | 1.18 (0.70–1.98) | 0.100 |
| T/T | 29 (10.9%) | 17 (11.9%) | 0.93 (0.45–1.90) | 16 (8.1%) | 16 (15.4%) | 2.39 (1.08–5.31) | |||
| Dominant (ref: G/G) | G/T-T/T | 152 (57.4%) | 79 (55.2%) | 0.83 (0.53–1.31) | 0.420 | 105 (53.3%) | 63 (60.6%) | 1.36 (0.83–2.21) | 0.220 |
| Recessive (ref: G/G + G/T) | T/T | 29 (10.9%) | 17 (11.9%) | 1.03 (0.53–2.04) | 0.920 | 16 (8.1%) | 16 (15.4%) | 2.20 (1.04–4.65) | 0.040 |
| rs3783521 | |||||||||
| A/A | 113 (42.6%) | 62 (43.7%) | 1.00 | 93 (47.0%) | 41 (39.0%) | 1.00 | |||
| Codominant | G/A | 123 (46.4%) | 64 (45.1%) | 0.86 (0.53–1.38) | 0.820 | 89 (45.0%) | 48 (45.7%) | 1.22 (0.73–2.04) | 0.110 |
| G/G | 29 (10.9%) | 16 (11.3%) | 0.92 (0.44–1.90) | 16 (8.1%) | 16 (15.2%) | 2.36 (1.07–5.22) | |||
| Dominant (ref: A/A) | G/A-G/G | 152 (57.4%) | 80 (56.3%) | 0.87 (0.55–1.37) | 0.540 | 105 (53.0%) | 64 (61.0%) | 1.39 (0.86–2.26) | 0.180 |
| Recessive (ref: A/A + G/A) | G/G | 29 (10.9%) | 16 (11.3%) | 0.99 (0.50–1.97) | 0.980 | 16 (8.1%) | 16 (15.2%) | 2.13 (1.01–4.49) | 0.048 |
SNP Single nucleotide polymorphism, OR Odds ratio; 95% CI: 95% confidence interval
pa-values were calculated by logistic regression analysis with adjustment for age in males
pb-values were calculated by logistic regression analysis with adjustment for age in females
Bold italics indicates the SNP with statistical significance (p < 0.05)