Fig. 7.

Effects of EGCG on the EGFR/RAS/RAF/MEK/ERK signaling pathway in human thyroid carcinoma cells. a Western blotting analysis of the expression levels of p-EGFR, EGFR, RAS, p-RAF, RAF, p-MEK1/2, MEK1/2, p-ERK1/2, and ERK1/2 in TT, TPC-1, and ARO cells. β-actin was used as the loading control. b–f The intensities of the bands were quantified by densitometry analyses and normalized by the amount of EGFR, β-actin, RAF, MEK1/2, and ERK1/2, respectively. Data are presented as mean ± SEM of three independent experiments. *P < 0.05, **P < 0.01 compared with the control group