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. 2019 Feb 28;19:45. doi: 10.1186/s12935-019-0744-y

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 10 — ORC1 was required for the XIST function in cervical cancer cell apoptosis. a, b Effect of ORC1 knock-down on cell apoptosis of Hela and C3AA cells was detected by flow cytometry. c, d C-caspase3, Bcl-2, total PARP, cleaved PARP protein expression in Hela and C3AA cell transfected si-ORC1alone or with miR-140-5p mimics or XIST. **P < 0.01, compared with NC