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. 2019 Feb 28;19:45. doi: 10.1186/s12935-019-0744-y

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — ORC1 was required for the XIST function in cervical cancer cell cycle. a Relative expression of ORC1 after Hela and C3AA cells transfected with si-ORC1 or empty vector. The negative effect of ORC1 downregulation on cell proliferation of Hela and C3AA cells was detected by CCK-8 assay (b, c) and EdU assay (d, e). f, g It was determined by flow cytometry that ORC1 downregulation had a suppressed effect on cell cycle of Hela and C3AA cells. And the suppressed effect was offset by miR-140-5p inhibitor or upregulation of XIST. **P < 0.01, compared with NC