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. 2019 Feb 28;5:5. doi: 10.1186/s40780-019-0134-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — A volcano plot for visualizing statistical significance (p-values) and the magnitude of alarm signals (reporting odds ratios; RORs) for 18 PTs that were used for detecting the development of acute pancreatitis (SMQ) during the administration of prednisolone, methylprednisolone and dexamethasone. RORs were calculated using the reported data including all levels of reporters’ certain about the causality

Negative common logarithm (to the base 10) of p-values (−log10 P) are plotted on the y-axis and natural logarithm (to the base e) of RORs (ln ROR) are plotted on x-axis. The horizontal line represents the threshold of significance (p = 0.05) corrected for multiple comparisons by Bonferroni’s method (p = 0.00093)