Table 4.

Spearman correlations between demographic, cognitive, or global neuropathological measures and tau markers in local axonal and somatodendritic compartments of the DG-mossy fiber pathway

Region	Tau Marker	Age	Braak Stage	Global CERADPlaque Density	Global Tangle Density	NIA-Reagan Score
DG Granule Cell Density	AT8	r = 0.299 p = 0.058	r = 0.472* p = 0.002	r = 0.069 p = 0.670	r = 0.504* p = 0.0008	r = 0.394 p = 0.01
	TNT2	r = 0.255 p = 0.113	r = 0.280 p = 0.080	r = 0.004 p = 0.702	r = 0.239 p = 0.137	r = 0.253 p = 0.116
Mossy Fiber Density	AT8	r = 0.446* p = 0.004	r = 0.337 p = 0.036	r = 0.205 p = 0.211	r = 0.418 p = 0.008	r = 0.470* p = 0.003
	TNT2	r = 0.477* p = 0.002	r = 0.484* p = 0.002	r = 0.156 p = 0.344	r = 0.539* p = 0.0004	r = 0.420 p = 0.008

PMI post-mortem interval, MMSE mini mental state exam, NIA-Reagan National Institute on Aging-Reagan Institute AD probability level, CA cornu ammonis, DG dentate gyrus; Braak stages ranged from 1 to 3. * indicates a significant correlation (p ≤ 0.005, adjusted p-value for multiple comparisons)