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. 2019 Feb 21;10:236. doi: 10.3389/fmicb.2019.00236

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Copyright © 2019 Stehlikova, Kostovcikova, Kverka, Rossmann, Dvorak, Novosadova, Kostovcik, Coufal, Srutkova, Prochazkova, Hudcovic, Kozakova, Stepankova, Rob, Juzlova, Hercogova, Tlaskalova-Hogenova and Jiraskova Zakostelska.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treatment by metronidazole did not change the severity of inflammation after IMQ application in germ-free (GF) BALB/c mice. (A,B) Quantification of ear thickness and ear histological score in GF controls and GF mice treated by metronidazole. (C,D) Comparison of the expression of CD3⁺RORγT⁺ in GF controls versus GF mice treated by metronidazole in spleen or inguinal lymph nodes. Percentage is relative to the proportion of live cells gated on CD3⁺ and subsequently on RORγt⁺ in control mice. 100% represents controls gated on live CD3⁺RORγt⁺. (E) Quantitative PCR analysis of mRNA expression of Il17f, Il23a, Il1b, Cxcl1, and Nfkbiz in the skin. The graphs show the results of one representative experiment out of two independent experiments (n = 6–7 mice per group). Differences between MET-treated group and control group were determined by unpaired Student’s t-test (A–E). *p < 0.05.