Table 1:
Reference | N | Years | Preparative regimen | Median age (range) | OS | GVHD | NRM | Relapse |
---|---|---|---|---|---|---|---|---|
Guardiola et al.14 | 55 | 1979–1997 | MAC (TBI, 63%) | 42 (4–53) | 5 years, 47% | aGVHD, 60% cGVHD, 60% | 27% | 18% |
Kerbauy et al.15 | 104 | 1990–2005 | MAC, 95; RIC, 9 | 49 (18–70) | 2 years, 70%; 5 years, 61% | aGVHD, 64% cGVHD, 84% | 32% | 10.5% |
Abelsson et al.16 | 92 | 1982–2009 | MAC, 40; RIC, 52 | 46 MAC 55 RIC | 2 years, 55%/75%; 5 years, 49%/59% | aGVHD, 75% MAC 28% RIC | 32% 24% | 10% |
Nivison-Smith et al.17 | 57 | 1993–2005 | MAC, 40; RIC, 17 | 47 (16–71) | 2 years, 59%/66%; 5 years, 58% | aGVHD, 37% | 25% | 12% |
Kroger et al.19 | 103 | 2002–2007 | RIC, all (BU/Flu) | 55 (32–68) | 5 years, 67% | aGVHD, 27% cGVHD, 49% | 19% | 29% |
Gupta et al.20 | 233 | 1997–2010 | RIC, all | 55 (19–79) | 5 years, 47% | aGVHD, 37% (day 100) cGVHD-42% | 18% | 43% |