. Author manuscript; available in PMC: 2019 Feb 28.

Published in final edited form as: Bone Marrow Transplant. 2015 Feb 9;50(5):628–636. doi: 10.1038/bmt.2014.323

Table 2:

Pathology of primary myelofibrosis (PMF) and changes in pathologic features observed after allo-SCT

Feature	Abnormality in PMF	Resolution after allo-SCT	Time when resolution occurs
Cellularity	Increased	Yes (up to 100%)	Upon engraftment
Megakaryocyte morphology	Hyperchromatic, ‘cloud-like’ nuclei, tight clustering	Variable; proportion with resolution unknown	Upon engraftment
Myeloid:erythroid ratio	Increased	Variable; proportion with resolution unknown	Upon engraftment
Reticulin fibrosis	Increased	Yes (40–93%)	6–23 months
Microvasculature	Increased density	Yes (50–100%)	3–12 months
Bone trabeculae	Thickened with new bone formation	Variable (0–50% at 12 months)	12 months or longer