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Schematic of A2 modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles delivery TMZ (A2-P(MIs)25/TMZ) for glioma synergetic TMZ and RT therapy. (A) (a) Prepare of A2-P(MIs)25/TMZ; (b) Mechanism of radiosensitization of P(MIs)25; (B) Schematic illustrating A2-P(MIs)25 as hypoxic tumor cell radiosensitizer delivery TMZ to achieve synergistic TMZ and RT treatment of glioma.
