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. 2019 Feb 21;10:275. doi: 10.3389/fimmu.2019.00275

Figure 1.

Figure 1

Effect of HCQ and BIIB059 on IFNα release from human whole blood stimulated with CpG-A, R848, or ssRNA. Whole blood from human healthy donors was stimulated or not with CpG-A (10 μM), R848 (1 μM), or ssRNA (4 μg/ml) complexed with pARG in presence or absence of HCQ (550 ng/ml), isotype control mAb (10 μg/ml), 24F4A (10 μg/ml) or a combination of both HCQ and 24F4A. Secreted IFNα was measured 18 h after stimulation in the serum using ELISA. Same color and/or shape-coded data points represent data obtained from a given donor (n = at least 6 donors). Statistical tests were performed using paired one-way Anova (ns, non-significant p ≥ 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).