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. 2019 Feb 21;10:275. doi: 10.3389/fimmu.2019.00275

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Copyright © 2019 Gardet, Pellerin, McCarl, Diwanji, Wang, Donaldson, Franchimont, Werth and Rabah.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The percentage of IFNα-producing pDCs upon stimulation with CpG-A, but not R848 or ssRNA, is negatively correlated with whole blood HCQ concentrations from CLE patients. (A) Association of the percentage of IFNα-producing pDCs identified by flow cytometry from PBMC after CpG-A (n = 22 donors), R848 (n = 22 donors), or ssRNA (n = 24 donors) stimulations with the HCQ concentrations in whole blood from CLE patients. Patients with non-detectable blood HCQ levels are shown at 0 ng/ml blood HCQ (B) Association of the change (ratio) between 3-month apart clinical visits in the percentage of IFNα-producing pDCs identified by flow cytometry from PBMC after CpG-A (n = 21 donors), R848 (n = 21 donors), or ssRNA (n = 22 donors) stimulation with the change in the blood HCQ concentration of CLE patients. Data points from patients with increase in blood HCQ concentration >600 ng/ml between the two visits are highlighted in red. Data points from patients with decrease in blood HCQ concentration >500 ng/ml between two visits are highlighted in green. Statistical association was assessed using Pearson's (P) and Spearman's rank (S) correlations.