Table 3.

FI-Lab21 at admission to hospital (FI-Lab21_admission), FI-Lab21 before discharge to hospital (FI-Lab21_discharge), and standard laboratory parameters compiling the FI-Lab21

At admission					Before discharge
Parameters	AUC (95% CI) for 6-month mortality	P-value	AUC (95% CI) for 1-year mortality	P-value	Parameters	AUC (95% CI) for 6-month mortality	P-value	AUC (95% CI) for 1-year mortality	P-value
FI-Lab21admission	0.72 (0.66–0.78)	<0.001	0.72 (0.67–0.78)	<0.001	FI-Lab21discharge	0.77 (0.71–0.82)	<0.001	0.75 (0.7–0.8)	<0.001
Blood sample at admission					Blood sample before discharge
White blood cells (n/µL)	0.51 (0.44–0.58)	0.791	0.51 (0.45–0.57)	0.725	White blood cells (n/µL)	0.59 (0.52–0.66)	0.011	0.58 (0.51–0.64)	0.015
Red blood cells (n/µL)	0.56 (0.49–0.62)	0.086	0.44 (0.38–0.5)	0.067	Red blood cells (n/µL)	0.56 (0.49–0.63)	0.081	0.56 (0.5–0.63)	0.04
MCV (fL)	0.50 (0.43–0.56)	0.932	0.48 (0.42–0.55)	0.615	MCV (fL)	0.50 (0.43–0.57)	0.987	0.51 (0.45–0.57)	0.737
Platelets (n/µL)	0.54 (0.48–0.61)	0.197	0.48 (0.41–0.54)	0.49	Platelets (n/µL)	0.58 (0.51–0.65)	0.028	0.57 (0.51–0.63)	0.02
Quick value (%)	0.54 (0.47–0.60)	0.306	0.41 (0.35–0.47)	0.003	Quick value (%)	0.55 (0.48–0.62)	0.140	0.54 (0.48–0.6)	0.204
PTT (seconds)	0.53 (0.46–0.6)	0.400	0.53 (0.47–0.59)	0.316	PTT (seconds)	0.58 (0.52–0.65)	0.015	0.57 (0.51–0.64)	0.019
Sodium (mval/L)	0.54 (0.47–0.60)	0.308	0.47 (0.41–0.53)	0.33	Sodium (mval/L)	0.54 (0.47–0.61)	0.234	0.53 (0.47–0.6)	0.273
Potassium (mg/dL)	0.55 (0.48–0.62)	0.147	0.52 (0.46–0.58)	0.567	Potassium (mg/dL)	0.54 (0.47–0.6)	0.313	0.52 (0.46–0.58)	0.544
Calcium (mval/L)	0.55 (0.48–0.62)	0.167	0.55 (0.49–0.61)	0.107	Calcium (mval/L)	0.63 (0.57–0.7)	<0.001	0.61 (0.55–0.67)	<0.001
Urea (mg/dL)	0.60 (0.54–0.67)	0.002	0.64 (0.48–0.69)	<0.001	Urea (mg/dL)	0.59 (0.52–0.65)	0.010	0.59 (0.53–0.65)	0.003
Total protein (g/dL)	0.59 (0.51–0.67)	0.024	0.59 (0.52–0.66)	0.015	Total protein (g/dL)	0.58 (0.5–0.66)	0.050	0.59 (0.52–0.66)	0.017
Creatinine (mg/dL)	0.56 (0.49–0.62)	0.089	0.55 (0.49–0.61)	0.03	Creatinine (mg/dL)	0.54 (0.48–0.61)	0.217	0.55 (0.49–0.6)	0.03
Bilirubin (mg/dL)	0.54 (0.47–0.61)	0.266	0.54 (0.48–0.6)	0.201	Bilirubin (mg/dL)	0.55 (0.48–0.62)	0.149	0.55 (0.49–0.62)	0.091
AST (U/L)	0.59 (0.51–0.66)	0.013	0.57 (0.51–0.63)	0.024	AST (U/L)	0.55 (0.49–0.62)	0.112	0.55 (0.48–0.61)	0.143
ALT (U/L)	0.56 (0.46–0.63)	0.235	0.55 (0.48–0.63)	0.153	ALT (U/L)	0.55 (0.47–0.62)	0.248	0.54 (0.47–0.61)	0.299
GGT (U/L)	0.56 (0.49–0.62)	0.092	0.57 (0.51–0.63)	0.023	GGT (U/L)	0.59 (0.52–0.65)	0.012	0.58 (0.53–0.64)	0.008
LDH (U/L)	0.6 (0.53–0.67)	0.005	0.6 (0.53–0.66)	0.001	LDH (U/L)	0.61 (0.54–0.67)	0.002	0.61 (0.55–0.67)	<0.001
Albumin (g/dL)	0.6 (0.52–0.67)	0.015	0.62 (0.55–0.67)	0.001	Albumin (g/dL)	0.59 (0.52–0.66)	0.024	0.61 (0.54–0.68)	0.003
CRP (mg/dL)	0.59 (0.53–0.65)	0.009	0.61 (0.56–0.67)	<0.001	CRP (mg/dL)	0.62 (0.56–0.68)	<0.001	0.61 (0.56–0.7)	<0.001
TSH (µU/mL)	0.50 (0.43–0.56)	0.881	0.52 (0.54–0.58)	0.607	TSH (µU/mL)	0.51 (0.44–0.58)	0.816	0.52 (0.45–0.58)	0.607
Spot urine					Spot urine
Total protein (mg/dL)	0.62 (0.55–0.69)	0.001	0.61 (0.54–0.67)	0.001	Total protein (mg/dL)	0.60 (0.53–0.67)	0.006	0.61 (0.54–0.67)	0.001

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUC, area under the receiver operating characteristic curve; CRP, C-reactive protein; FI-Lab21, 21-item frailty index based on laboratory blood and urine tests; FI-Lab21_admission, frailty index obtained at admission to hospital; FI-Lab21_discharge, frailty index obtained before discharge from hospital; GGT, gamma-glutamyl transferase; LDH, lactate dehydrogenase; MCV, mean corpuscular volume; PTT, partial thromboplastin time; TSH, thyroid-stimulating hormone.