Fig. 1.

(A) Number of crosslinks identified at 1% FDR in the ReACT and Mango datasets when filtering by maximum Comet expect score versus XLinkProphet probability. (B) Protein-protein interaction network showing 709 non-redundant crosslinks at predicted 1% FDR in the combined ReACT and Mango datasets. Nodes indicate crosslink sites in proteins and are grouped together by Uniprot ID (blue label). Edges correspond to crosslinks and are colored based on known interactions, as indicated in the legend. False positive protein PKSJ_BACSU is indicated as a green node