Table 4.
Model-Adjusted Mean BITSEA Scores by Neuroimaging Findings at 18- to 22-Months
| Neuroimaging Findings | Problem |
Competence |
||
|---|---|---|---|---|
| Adjusted Mean (95% CI) | p-value | Adjusted Mean (95% CI) | p-value | |
| Early CUS | ||||
| Normal | 12.6 (11.4, 13.7) | REF | 16.5 (15.8, 17.3) | REF |
| No IVH grade 3–4/cPVL | 12.8 (10.9, 14.6) | 0.798 | 16.5 (15.4, 17.5) | 0.883 |
| IVH grade 3–4/cPVL | 12.3 (9.9, 14.6) | 0.801 | 17.2 (15.9, 18.5) | 0.283 |
| Late CUS | ||||
| Normal | 12.9 (11.7, 14.1) | REF | 16.8 (16.0, 17.5) | REF |
| No IVH grade 3–4/cPVL | 11.9 (10.2, 13.6) | 0.230 | 16.0 (15.0, 17.0) | 0.091 |
| IVH grade 3–4/cPVL | 10.9 (7.8, 14.0) | 0.200 | 17.0 (15.3, 18.6) | 0.799 |
| Severity of WMA | ||||
| Normal | 12.7 (11.0, 14.4) | REF | 16.9 (16.0, 17.9) | REF |
| Mild | 12.7 (11.4, 14.0) | 0.982 | 16.4 (15.7, 17.2) | 0.272 |
| Moderate | 12.0 (9.9, 14.0) | 0.534 | 16.8 (15.7, 17.9) | 0.865 |
| Severe | 12.4 (8.7, 16.0) | 0.857 | 16.1 (14.2, 18.1) | 0.436 |
| Lesions | ||||
| No lesions | 12.6 (11.3, 13.8) | REF | 16.8 (16.1, 17.6) | REF |
| Non-cerebellar lesions only | 12.1 (10.5, 13.6) | 0.551 | 16.5 (15.6, 17.4) | 0.452 |
| Cerebellar lesions | 13.5 (11.6, 15.5) | 0.339 | 15.7 (14.6, 16.8) | 0.040 |
| Significance of cerebellar lesions | ||||
| No cerebellar lesions | 12.4 (11.2, 13.5) | REF | 16.7 (16.0, 17.4) | REF |
| Non-significant lesions | 14.2 (11.3, 17.1) | 0.230 | 15.9 (14.4, 17.4) | 0.261 |
| Significant lesions | 13.2 (10.7, 15.6) | 0.517 | 15.7 (14.4, 17.0) | 0.092 |
Note: REF=reference category; means are adjusted for center, birthweight, gestational age, multiple gestation, race/ethnicity, Medicaid enrollment, gender, antenatal steroids, C-section, late-onset sepsis, surgery for ROP, NEC, or PDA, postnatal steroids, and BPD.