Table 2.
Cox regression analyses for all individual SNPs using the number of genotypes dichotomized (uni- and multi-variate analyses)
| Gene | Pathways (established or potential, leading to VTE) | SNP | Dichotomization of genotypes | Univariate | Adjusted for sex, age and family history of VTE |
|---|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | ||||
| A2M | Coagulation | rs3832852 | 2 vs 0 + 1 | 2.66 (1.08–6.52) | 2.60 (1.06–6.40) |
| ABO | Coagulation | rs8176719 | 1 + 2 vs 0 | 2.05 (1.21–3.46) | 1.97 (1.16–3.34) |
| FGG | Coagulation | rs2066865 | 2 vs 0 + 1 | 1.82 (1.11–3.01) | 1.77 (1.07–2.93) |
| FV | Coagulation | rs6025 | 1 + 2 vs 0 | 1.71 (1.20–2.44) | 1.62 (1.12–2.33) |
| PAI-1 | Fibrinolytic | rs1799889 | 1 + 2 vs 0 | 1.59 (1.06–2.38) | 1.58 (1.05–2.38) |
| F11 | Coagulation | rs2036914 | 2 vs 0 + 1 | 1.51 (1.00-2.29) | 1.54 (1.02–2.34) |
| FTO | Lipid metabolism | rs9939609 | 2 vs 0 + 1 | 1.40 (0.93–2.12) | 1.45 (0.96–2.20) |
| FII | Coagulation | rs1799963 | 1 + 2 vs 0 | 1.39 (0.68–2.85) | 1.39 (0.67–2.85) |
| ApoM | Lipid metabolism | rs805297 | 1 + 2 vs 0 | 1.34 (0.94–1.92) | 1.36 (0.95–1.94) |
| MRPL37 | mtDNA regulation | rs10888838 | 1 + 2 vs 0 | 1.32 (0.89–1.96) | 1.29 (0.86–1.93) |
| THBD | Coagulation | rs1042580 | 1 + 2 vs 0 | 1.29 (0.90–1.86) | 1.26 (0.87–1.82) |
| TFAM | mtDNA regulation | rs1937 | 1 + 2 vs 0 | 1.25 (0.84–1.85) | 1.24 (0.83–1.84) |
| THBD | Coagulation | rs3176123 | 1 + 2 vs 0 | 1.12 (0.79–1.60) | 1.11 (0.78–1.59) |
| THBD | Coagulation | rs1042579 | 1 + 2 vs 0 | 1.12 (0.78–1.59) | 1.11 (0.77–1.58) |
| P-Selectin | Inflammation | rs6136 | 1 + 2 vs 0 | 1.01 (0.66–1.55) | 1.04 (0.67–1.60) |
| IL1RL1 | Inflammation | rs3821204 | 1 + 2 vs 0 | 0.93 (0.65–1.32) | 0.94 (0.66–1.34) |
| THBD | Coagulation | rs1962 | 1 + 2 vs 0 | 0.90 (0.63–1.29) | 0.92 (0.64–1.31) |
| TLR9 | Inflammation | rs5743836 | 1 + 2 vs 0 | 0.87 (0.58–1.31) | 0.85 (0.56–1.28) |
| PARK2 | mtDNA regulation | rs4708928 | 1 + 2 vs 0 | 0.84 (0.58–1.23) | 0.80 (0.54–1.16) |
| ApoM | Lipid metabolism | rs9404941 | 1 + 2 vs 0 | 0.80 (0.46–1.39) | 0.81 (0.46–1.41) |
| IL1RL1 | Inflammation | rs950880 | 1 + 2 vs 0 | 0.78 (0.55–1.10) | 0.78 (0.55–1.11) |
| FII | Coagulation | rs3136520 | 1 + 2 vs 0 | 0.74 (0.33–1.68) | 0.77 (0.34–1.75) |
HR hazard ratio of recurrent VTE for high vs low, 0 = wildtype homozygous, 1 = heterozygous, 2 = mutant homozygous, mtDNA = mitochondrial DNA