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. 2018 Nov 8;21(1):25–32. doi: 10.1007/s12017-018-8517-7

Fig. 3.

Fig. 3

Phosphorylated AMPK/AMPK ratio is significantly reduced in the ventral midbrain region of aged wild-type mice. a Left, immunoblots showing the levels of pAMPK and AMPK in the same selected brain regions of aged wild-type mice (20 month old, n = 4) compared to young wild-type mice (2 month old, n = 4). Right, bar graph showing the average densitometric value of pAMPK/AMPK ratio in these regions. b Top, immunoblots showing the levels of Parkin in same selected brain regions of wild-type mice. Bottom, bar graph showing the average densitometric value of Parkin levels in these regions (n = 5). c Same as b except that PARIS expression is shown here (n = 5). The blots above were stripped and reprobed with anti-actin antibody to reflect loading variations. (*p < 0.05, **p < 0.001 compared to Ctx, #p < 0.05 compared to Str)