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. 2018 Nov 8;21(1):25–32. doi: 10.1007/s12017-018-8517-7

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Phosphorylated AMPK/AMPK ratio is significantly reduced in the ventral midbrain region of Parkin null or PINK1 null mice brain. a Left, immunoblots showing the levels of pAMPK, AMPK, PGC-1α, PARIS, and Parkin in the three selected brain regions of 4–6-month-old wild-type (+/+) and Parkin null (−/−) mice. Right, bar graphs showing the average densitometric value of pAMPK/AMPK ratio and PGC-1α level in these regions (n = 7). (B) Left, immunoblots showing the levels of pAMPK, AMPK, and PGC-1α in the three selected brain regions of 7-month-old wild-type (+/+) and PINK1 null (−/−) mice. Right, bar graphs showing the average densitometric value of pAMPK/AMPK ratio and PGC-1α level in these regions (n = 4). The blots above were stripped and reprobed with anti-actin antibody to reflect loading variations. All the experiments above were repeated at least three times. (*p < 0.05 and **p < 0.001 compared to respective wild-type region)