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Metformin treatment selectively restores midbrain pAMPK/AMPK in Parkin null mice. Immunoblots show the levels of pAMPK, AMPK, PGC-1α, and PARIS in the ventral midbrain (VM) tissues of 9-month-old Parkin null mice in the absence or presence of metformin treatment (n = 4). Bar graphs show the average densitometric value of pAMPK/AMPK ratio, PGC-1α, and PARIS in untreated and treated Parkin null mice (*p < 0.05 compared to control diet)
