Table A5:
GRADE Evidence Profile for Non-randomized Studies Investigating the Effect of Patient Adherence on Outcomes, Quality of Life, and Adverse Effects
| No. of Studies (Design) | Risk of Bias | Inconsistency | Indirectness | Imprecision | Publication Bias | Upgrade Considerations | Quality |
|---|---|---|---|---|---|---|---|
| Recurrence rate | |||||||
| 2 observational29,31 | No serious limitations | No serious limitations | No serious limitations | No serious limitations | Not detected | No serious limitations | ⊕⊕ Low |
| Quality of life | |||||||
| 1 observational30 | No serious limitations | No serious limitations | Serious limitationsa | No serious limitations | Not detected | No serious limitations | ⊕ Very low |
| Adverse effects | |||||||
| 1 observational30 | No serious limitations | No serious limitations | Serious limitationsa | No serious limitations | Not detected | No serious limitations | ⊕ Very low |
a
Population was similar but not identical to those under consideration.
Note: Absence of randomization and control for confounding, an inherent limitation of the observational studies, is factored in the last column when we graded the quality.